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Serum Glutamate (Alpha-Ketoglutarate) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of glutamate, a key chemical involved in brain function and energy production, in your blood serum.

Quick summary

["Glutamate helps support brain health and energy balance; abnormal levels may signal metabolic or neurological concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47627-5
Short code
Glutamate SFr SerPl
Synonyms
Glutamate SFr SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Glutamate?

Glutamate is an essential amino acid and neurotransmitter in the brain. It plays a critical role in transmitting signals between nerve cells and maintaining normal brain function. Outside the brain, glutamate also acts as a metabolic intermediate in energy production.

Why Might This Test Be Ordered?

Your healthcare provider may order this test if you have symptoms like confusion, seizures, or unexplained fatigue. It could also be part of a broader evaluation for conditions affecting metabolism, nerve function, or brain chemistry.

What Does the Result Mean?

Results are not typically provided as a single reference range for glutamate in serum, as levels can vary based on health status, diet, and other factors. Your provider will interpret the result in the context of your symptoms and medical history.

How Is This Test Done?

A blood sample is drawn from a vein, usually in your arm. The serum portion is then analyzed using a specialized laboratory technique to measure glutamate concentration.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Glutamate Level

Frequently asked questions

What causes abnormal glutamate levels?
Abnormal glutamate levels can result from metabolic disorders, neurological conditions, or medications that affect brain chemistry. Conditions like mitochondrial diseases or certain genetic disorders may also influence glutamate production or breakdown.
How long does it take to get results?
Test results are typically available within 1 to 3 business days, depending on your lab’s processing schedule. Your provider will contact you once the results are ready.
Can diet affect this test?
Yes, certain foods and supplements—such as those high in glutamate (e.g., monosodium glutamate) or amino acids—may influence glutamate levels temporarily. Your provider may recommend fasting or avoiding specific foods before testing if instructed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy