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Glutamine and Histidine to Creatinine Ratio, Urine

Published: August 9, 2026Updated: August 16, 2026

This urine test measures glutamine and histidine relative to creatinine, which helps account for differences in urine concentration.

Quick summary

["The result helps assess urinary glutamine and histidine while adjusting for urine concentration."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58927-5
Short code
Glutamine+Histidine/Creat Ur-Rto
Synonyms
Glutamine+Histidine/Creat Ur-Rto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amounts of the amino acids glutamine and histidine in urine and compares them with the amount of creatinine. Creatinine is commonly used as a reference marker for urine concentration.

Why might I need this test?

A clinician may order this test as part of an evaluation of nutrition, protein metabolism, kidney function, or an inherited metabolic condition. It is usually interpreted together with symptoms, diet, medications, and other laboratory results.

How is the test performed?

A urine sample is collected and tested to determine the amounts of glutamine, histidine, and creatinine. The laboratory then reports the glutamine and histidine results relative to creatinine.

How do I prepare for the test?

Follow your clinician's urine-collection instructions exactly, including any requested collection time or handling requirements. Your current diet, supplements, and medications may affect the results, so tell the healthcare provider about them.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine glutamine/histidine-to-creatinine ratio

Frequently asked questions

What does the urine creatinine ratio show?
It compares urinary glutamine and histidine with creatinine. This can make the amino acid results easier to interpret when urine concentration varies.
Is this the same as a standard urine amino acid test?
Not necessarily. This test specifically reports glutamine and histidine relative to creatinine, while broader urine amino acid testing may measure many more amino acids.
Do I need to change my diet before the test?
Do not make major dietary changes unless your clinician instructs you to do so. Inform the healthcare provider about protein intake, supplements, and medications because these may affect interpretation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy