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Glycine concentration (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of glycine, an amino acid, in your blood plasma or serum. Glycine plays a role in protein synthesis, metabolism, and neurotransmitter production.

Quick summary

["Glycine levels can help diagnose or monitor certain metabolic conditions or kidney function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13397-5
Short code
Glycine Amn-mCnc
Synonyms
Glycine Amn-mCnc
Category
glucose
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

What Glycine Does in Your Body

Glycine is essential for forming proteins, including collagen, and helps break down certain substances in your body. It also supports nerve function and energy production. Abnormal levels may indicate issues with metabolism or kidney function.

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms like fatigue, muscle weakness, or signs of metabolic disorders. It could also be part of a broader evaluation for kidney disease or other conditions affecting amino acid metabolism.

Common Conditions Monitored

While glycine itself isn’t directly linked to many common conditions, low levels may be associated with certain metabolic disorders or kidney problems. High levels could suggest liver disease or other metabolic imbalances.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is then separated into plasma or serum for testing. This test is typically done on fresh or stored blood samples sent to a lab for analysis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Serum/plasma glycine

Frequently asked questions

What might cause abnormal glycine levels?
Glycine levels can be affected by kidney disease, liver disease, certain genetic metabolic disorders, or conditions that disrupt protein metabolism. Your provider will consider your symptoms, medical history, and other test results when interpreting the results.
How are glycine levels interpreted?
Results are compared to a reference range specific to your lab. While exact ranges vary, very low levels may suggest metabolic issues, and very high levels could indicate liver or kidney problems. Your provider will discuss what the results mean for you.
Do I need to prepare for this test?
No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if glycine levels are being evaluated in the context of other metabolic conditions. Always follow your provider’s instructions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy