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Glycine Serum Concentration (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of glycine, an amino acid, in your serum. Glycine plays a role in protein synthesis, energy production, and neurotransmitter function.

Quick summary

["Understanding your glycine levels may help assess metabolic or protein-related health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47637-4
Short code
Glycine SFr Amn
Synonyms
Glycine SFr Amn
Category
glucose
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

What Glycine Does in Your Body

Glycine is one of the simplest amino acids and serves as a building block for proteins. It also helps produce glucose for energy and supports nerve function. Your body naturally produces glycine, but certain conditions or medications may affect its levels.

Why This Test Might Be Ordered

Doctors may order glycine testing if you have symptoms like fatigue, muscle weakness, or metabolic disorders. It can also be part of broader evaluations for conditions affecting amino acid metabolism or protein synthesis.

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The blood is then processed to separate serum, which is sent to the lab for analysis. This test does not require fasting unless specified by your healthcare provider.

What the Results Mean

Results are typically reported as a concentration in milligrams per deciliter (mg/dL) or millimoles per liter (mmol/L). While reference ranges vary by lab, abnormal results may indicate metabolic issues or other underlying health concerns.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated glycine levels might suggest conditions like glycine encephalopathy or certain genetic disorders affecting amino acid metabolism. Low levels could be linked to severe metabolic disorders or kidney issues, though interpretation depends on clinical context and other test results. Always discuss findings with your healthcare provider.

Short name

Glycine Level

Frequently asked questions

How is glycine tested?
This test uses a specialized laboratory method, likely enzymatic or chromatographic, to measure glycine concentration in your serum. The process involves precise analysis to ensure accurate results.
Is fasting required for this test?
No fasting is typically required unless your doctor specifies otherwise. Blood is drawn at a convenient time for you, and results are used to assess your overall metabolic health.
Can glycine levels change with diet?
Yes, diet can influence glycine levels, especially if you consume foods high in protein or certain supplements. However, glycine is also produced naturally in the body, so dietary changes alone may not drastically alter test results unless related to a specific metabolic condition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy