Glyoxylate-to-Creatinine Ratio, Urine
Measures urine glyoxylate relative to creatinine to help evaluate oxalate metabolism, particularly when a kidney stone disorder such as primary hyperoxaluria is suspected.
["An elevated urine glyoxylate-to-creatinine ratio may indicate increased oxalate production from a metabolic disorder."]
Key facts at a glance
- LOINC
- 25107-4
- Short code
- Glyoxylate/Creat Ur-sRto
- Synonyms
- Glyoxylate/Creat Ur-sRto
- Category
- kidney
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test measures the amount of glyoxylate in urine compared with the amount of creatinine. Glyoxylate is a metabolic substance that can be converted to oxalate, a component of many kidney stones. The creatinine ratio helps account for differences in urine concentration.
Why might I need this test?
Your clinician may order this test if you have recurring kidney stones, high urinary oxalate, or unexplained kidney findings. It can help evaluate inherited disorders of oxalate metabolism, including primary hyperoxaluria.
How is the test performed?
A urine sample is collected and tested in the laboratory for glyoxylate and creatinine. The laboratory then calculates the glyoxylate-to-creatinine ratio. The required collection method and timing depend on your clinician's order.
How do I prepare for the test?
Follow the collection instructions provided by your healthcare professional. If a complete 24-hour urine collection is requested, collect all urine for the specified period and store it as instructed; otherwise, provide the urine sample in the container supplied.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
An elevated ratio may indicate increased urinary glyoxylate, which can occur in primary hyperoxaluria and other conditions that affect oxalate metabolism. Results should be interpreted with kidney function, urine oxalate levels, stone history, and other clinical findings. This test alone does not establish a genetic diagnosis.
Short name
Urine glyoxylate/creatinine ratio
Frequently asked questions
What does the glyoxylate-to-creatinine ratio measure?
Why is glyoxylate testing important for kidney stones?
Does an abnormal result diagnose primary hyperoxaluria?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy