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Ganglioside GM1 (Mass Concentration) in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of a specific type of fat-like substance called ganglioside GM1 in your blood serum. It may be used to help diagnose or monitor certain neurological conditions.

Quick summary

["This test helps assess rare genetic or metabolic disorders affecting nerve cells."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
111356-2
Short code
GM1 Gangl IgM Msmt Ser
Synonyms
GM1 Gangl IgM Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Might This Test Be Ordered?

Your healthcare provider may recommend this test if you have symptoms like muscle weakness, developmental delays, or neurological issues. It could also be part of a broader evaluation for inherited metabolic disorders or lysosomal storage diseases.

What Does This Test Involve?

A blood sample is drawn from a vein in your arm. The serum portion is then analyzed using a specialized laboratory technique to measure GM1 levels.

What Does a Result Mean?

Results are not typically provided as a single reference range since GM1 levels can vary widely depending on the underlying condition. Your provider will interpret the result in the context of your symptoms, medical history, and other test results.

Common Conditions Monitored

Elevated or abnormal levels of GM1 may be linked to conditions like GM1 gangliosidosis (a lysosomal storage disorder) or other rare genetic disorders affecting nerve function. This test is not routinely used for general screening.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: Elevated GM1 levels may indicate lysosomal storage diseases or other metabolic disorders affecting ganglioside metabolism, often requiring specialized pediatric or genetic evaluation. Results should be reviewed by a healthcare provider experienced in rare genetic conditions.

Short name

GM1 Ganglioside Serum

Frequently asked questions

What does a high or low GM1 level mean?
A high GM1 level may suggest a lysosomal storage disorder or other metabolic condition affecting nerve cells. A low level is less commonly associated with specific conditions but may be part of a broader diagnostic workup.
How often should I get this test?
This test is usually ordered as part of a specific diagnostic evaluation, not as a routine check. Follow your healthcare provider’s instructions for follow-up testing.
Is this test painful?
The blood draw may cause mild discomfort, but it typically lasts only a few minutes. Most people experience only minor bruising or soreness afterward.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy