Skip to content

Ganglioside GM2 (via Line Blot Immunoassay)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of GM2 ganglioside, a complex sugar molecule found in certain tissues, often analyzed to identify metabolic or genetic conditions affecting lipid metabolism.

Quick summary

["GM2 ganglioside testing may help diagnose rare genetic disorders linked to abnormal lipid storage."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
89517-7
Short code
GM2 Gangl IgG+IgM Ser Ql Line blot
Synonyms
GM2 Gangl IgG+IgM Ser Ql Line blot
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
line-blot
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like developmental delays, neurological issues, or a family history of GM2-related disorders. It could also be part of a broader evaluation for inherited metabolic diseases.

What to Expect Before the Test

No special preparation is typically needed, but you may be asked to fast for a certain period if blood is drawn. If urine or other samples are involved, follow any specific instructions your doctor provides.

Sample Collection Process

Blood, cerebrospinal fluid, or other body fluids may be collected via a simple blood draw or other procedures. The test involves detecting GM2 ganglioside using a specialized line blot immunoassay technique.

What the Results Mean

Results may indicate normal levels, elevated levels (suggesting a potential metabolic disorder), or other variations. Elevated GM2 ganglioside is often associated with conditions like Tay-Sachs disease or other GM2 storage disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

GM2 Ganglioside Screening/Confirmatory Test

Frequently asked questions

What Does Elevated GM2 Ganglioside Indicate?
Elevated GM2 ganglioside levels can signal inherited metabolic disorders affecting nerve cells, such as Tay-Sachs disease or Sandhoff disease. These conditions can cause progressive neurological damage, so early detection is critical for management and support.
How Often Should This Test Be Done?
If you have a confirmed diagnosis of a GM2-related disorder, your doctor may recommend periodic monitoring. For those without symptoms but with a family history, testing may be less frequent or only done under specific circumstances.
Can Diet or Supplements Affect This Test?
No specific diet or supplements are known to interfere with GM2 ganglioside testing. However, always inform your healthcare provider about any medications or supplements you take, as they may indirectly influence test results or your health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy