Ganglioside GM2 (Serum) Qualitative Line Blot Assay
This test detects the presence of GM2 ganglioside, a type of lipid involved in nerve cell function, using a specialized line blot technique on serum. It may be used to evaluate conditions affecting lipid metabolism or nerve tissue.
["This test helps identify potential genetic or metabolic disorders linked to abnormal GM2 levels."]
Key facts at a glance
- LOINC
- 89525-0
- Short code
- GM2 Gangl IgG Ser Ql Line blot
- Synonyms
- GM2 Gangl IgG Ser Ql Line blot
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- line-blot
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is This Test Measuring?
The GM2 ganglioside is a complex carbohydrate-lipid molecule found in nerve cells. In this test, a small sample of your serum is analyzed to check for its presence. The line blot method detects specific patterns that indicate whether GM2 is present in expected or abnormal amounts.
Why Might Your Doctor Order This Test?
Your doctor may recommend this test if you have symptoms suggestive of a metabolic disorder, such as developmental delays, muscle weakness, or neurological issues. It could also be part of a broader evaluation for conditions like Tay-Sachs disease or other lysosomal storage disorders.
How Is the Sample Collected?
A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate the serum, which is sent to the lab for testing. No special preparation is needed before the test.
What Are Possible Results?
The test result will indicate whether GM2 ganglioside is detected (qualitative result). If present, it may suggest a metabolic disorder requiring further evaluation. If absent, it may indicate a normal result, but follow-up testing could still be needed for diagnosis.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Abnormal detection of GM2 ganglioside can be associated with lysosomal storage disorders, such as Tay-Sachs disease, which affects nerve cells and can lead to developmental delays, seizures, or other neurological symptoms. Early detection can guide treatment decisions and management strategies.
Short name
GM2 Ganglioside Screening
Frequently asked questions
What Does a Positive or Negative Result Mean?
How Often Should This Test Be Repeated?
Can Diet or Lifestyle Affect This Test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy