Ganglioside GM2 (Serum) by Line Blot Assay
This test measures the presence of GM2 ganglioside in your blood, a lipid molecule that can help identify certain inherited metabolic disorders, including Tay-Sachs disease.
["This screening helps detect genetic conditions affecting lipid metabolism."]
Key facts at a glance
- LOINC
- 89524-3
- Short code
- GM2 Gangl IgM Ser Ql Line blot
- Synonyms
- GM2 Gangl IgM Ser Ql Line blot
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- line-blot
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your healthcare provider may order this test if you have symptoms like developmental delays, muscle weakness, or neurological issues that could be linked to GM2 ganglioside-related disorders. It’s also used in research or genetic counseling settings for families with a history of these conditions.
What to Expect Before the Test
No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. It usually takes about 15 minutes. If you’re nervous, let your provider know—we can help make it more comfortable.
What the Results Mean
Results are qualitative (yes/no presence) rather than quantitative. Elevated levels of GM2 ganglioside may suggest Tay-Sachs disease or other lysosomal storage disorders, prompting further genetic testing or specialist evaluation.
Common Symptoms Linked to This Test
Conditions like Tay-Sachs disease often present in infancy with symptoms such as loss of developmental milestones, seizures, or difficulty moving. Early detection through screening can improve long-term outcomes.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: This test is primarily used as a screening tool for inherited metabolic disorders. GM2 ganglioside accumulation is characteristic of lysosomal storage diseases, including Tay-Sachs disease, which affects nerve cells and can lead to severe neurological impairment. Results guide next steps, such as genetic counseling or specialized care.
Short name
GM2 Ganglioside Screening
Frequently asked questions
What does a positive result mean?
How often should I get this test?
Can lifestyle changes affect this test result?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy