Line Blot Analysis for Antibodies Against Specific Antigens (e.g., Myelin Oligodendrocyte Glycoprotein, MOG)
This test detects antibodies in your blood that target a protein called Myelin Oligodendrocyte Glycoprotein (MOG), which is involved in the protective covering of nerve fibers. It may help diagnose or evaluate certain types of autoimmune conditions affecting the central nervous system.
["This test helps identify potential immune responses linked to demyelinating diseases."]
Key facts at a glance
- LOINC
- 89510-2
- Short code
- GM3 IgM Ser Ql Line blot
- Synonyms
- GM3 IgM Ser Ql Line blot
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- line-blot
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like vision changes, muscle weakness, or neurological issues that suggest conditions such as multiple sclerosis (MS) or other demyelinating diseases. It may also be used in cases where other tests are inconclusive or to guide treatment decisions.
How the Test Works
A small blood sample is taken and analyzed using a line blot technique. This method detects specific antibodies in your serum or plasma that bind to MOG or other antigens. The results are presented as positive or negative for the presence of these antibodies.
Sample Collection and Preparation
A vein in your arm will be cleaned and a needle inserted to draw blood. You may feel a slight pinch, but it usually doesn’t cause significant discomfort. The blood sample is then processed and sent to the lab for testing.
What to Expect Before the Test
No special preparation is needed for this test. You can eat, drink, or take medications as usual. If you are on blood-thinning medications, let your healthcare provider know before the test.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Positive results for MOG antibodies may suggest an autoimmune response targeting the myelin sheath of nerves, potentially indicating conditions like MOG-associated disease (a type of demyelinating disorder) or other neurological autoimmune conditions. These antibodies can be associated with symptoms such as optic neuritis, transverse myelitis, or acute disseminated encephalomyelitis. However, results alone do not diagnose a specific condition and should be interpreted alongside clinical findings and other tests.
Short name
MOG Antibody Line Blot Test
Frequently asked questions
What Does a Positive or Negative Result Mean?
Can This Test Be Used to Diagnose Multiple Sclerosis?
How Often Should I Get This Test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy