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Immunoglobulin G (IgG) Subclass 1, Serum Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Immunoglobulin G (IgG) subclass 1, a type of antibody in your blood. IgG1 is one of the main components of your immune system, helping fight infections and diseases.

Quick summary

["IgG1 helps protect your body by identifying and neutralizing harmful substances."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
108198-3
Short code
GM4 IgG+IgM Ser Ql IA
Synonyms
GM4 IgG+IgM Ser Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

IgG1 is part of the broader immunoglobulin family, which includes antibodies that play a critical role in your immune response. This test specifically looks at the concentration of IgG1 in your serum, which can vary depending on your health status, immune function, and exposure to infections or vaccines.

Why Might You Need This Test?

Doctors may order an IgG1 test to evaluate immune function, diagnose conditions like immunodeficiency, assess response to treatments, or investigate symptoms such as frequent infections, fatigue, or autoimmune issues. It can also help monitor certain chronic diseases or immune-related disorders.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate the serum, which is sent to a lab for analysis. The lab uses an immunoassay method to measure the IgG1 concentration.

What Are Possible Results?

Results are typically reported as a concentration value in milligrams per deciliter (mg/dL) or grams per liter (g/L). While specific reference ranges can vary by lab, lower than expected levels may indicate immune deficiencies, while higher levels might be seen in chronic infections or certain autoimmune conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

IgG1 levels can be useful in diagnosing or managing conditions affecting the immune system. For example, low IgG1 levels might suggest a primary immunodeficiency, while abnormal levels can help guide treatment decisions, such as adjusting immune-boosting therapies or identifying underlying infections.

Short name

IgG1 Level

Frequently asked questions

What does a low IgG1 level mean?
A low IgG1 level may indicate an immune system that is not functioning as well as it should, which could be due to a primary immunodeficiency, certain medications, or chronic health conditions. Your doctor will consider your overall health and symptoms to interpret the result.
What causes elevated IgG1 levels?
Elevated IgG1 levels can sometimes be seen in chronic infections, autoimmune diseases, or as a response to certain treatments or vaccines. It’s important to discuss these findings with your healthcare provider to explore possible causes and next steps.
How often should I get this test?
The frequency of this test depends on your medical condition and treatment plan. Your doctor will determine if and when to repeat the test based on your symptoms, response to treatment, or other clinical needs.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy