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Genetic Resistance to Penicillin by Lipid Susceptibility Test (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures how penicillin interacts with bacterial lipids in your blood, helping determine if certain bacteria may resist penicillin treatment.

Quick summary

["Assists doctors in choosing the right antibiotic for infections caused by bacteria that might not respond to penicillin."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
93698-9
Short code
GN resist Pnl Islt/Spm
Synonyms
GN resist Pnl Islt/Spm
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

This test evaluates the susceptibility of bacterial lipids to penicillin by analyzing how the antibiotic affects them in your serum. It’s part of a broader effort to identify bacterial strains that could be resistant to penicillin-based medications.

Why It’s Done

Doctors may order this test if you have an infection suspected to involve bacteria that could be resistant to penicillin, or if you’ve previously been treated with penicillin without success. It helps guide treatment decisions to ensure effective antibiotic therapy.

How It Works

A small sample of your serum is tested to see how penicillin interacts with bacterial components. The test measures changes in lipid properties that indicate resistance, often using specialized laboratory techniques like electrophoresis or nephelometry.

What to Expect Before the Test

No special preparation is needed. You may have a simple blood draw, similar to other routine blood tests. If you’re on blood-thinning medication, let your doctor know before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Results help identify bacterial strains that may not respond to penicillin. If resistance is confirmed, doctors can switch to alternative antibiotics that are more effective. Early detection can prevent treatment failures and reduce the risk of antibiotic-resistant infections.

Short name

Penicillin Resistance Screening (Serum)

Frequently asked questions

How long does it take to get results?
Test results are typically available within 1 to 3 business days, depending on lab processing times. Your doctor will contact you once results are ready.
What does a positive result mean?
A positive result suggests that the bacteria in your infection may be resistant to penicillin. This doesn’t mean you’ll automatically need a different antibiotic, but it guides your doctor’s treatment plan to ensure the right medication is chosen.
Can I take antibiotics before this test?
It’s important to avoid taking antibiotics unless prescribed by your doctor, as this could affect the accuracy of the test. If you’ve already taken antibiotics, inform your healthcare provider so they can interpret the results correctly.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy