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Total Protein with Albumin/Globulin Separation (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total protein in your blood and breaks it down into albumin and globulin fractions, which help assess protein balance and potential issues like malnutrition or liver/kidney problems.

Quick summary

["A protein profile helps doctors check if your blood has the right mix of proteins for good health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
56269-4
Short code
Goat Milk IgG4-mCnc
Synonyms
Goat Milk IgG4-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Protein is essential for many body functions, including tissue repair, immune support, and fluid balance. Albumin, the main protein in blood, helps maintain proper fluid levels, while globulins support immune function. Abnormal levels can signal conditions like liver disease, kidney problems, or malnutrition.

How the Test Works

Blood is drawn and separated into components. The total protein is measured directly, while albumin and globulin are often separated using electrophoresis or other methods to show their individual amounts.

What to Expect Before the Test

No special preparation is needed, but you may want to avoid heavy meals 2 hours before your blood draw. Stay hydrated unless your doctor advises otherwise.

Possible Results & Next Steps

Results may show if your protein levels are too high or too low. High total protein could indicate dehydration or conditions like multiple myeloma. Low levels might suggest liver disease, kidney problems, or poor nutrition. Your doctor will discuss results with you and may recommend follow-up tests if needed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Protein Profile

Frequently asked questions

What causes abnormal protein levels?
Abnormal protein results can be caused by many factors, including chronic diseases (like liver or kidney disease), infections, inflammatory conditions, or nutritional deficiencies. For example, low albumin might be linked to liver failure or severe protein loss, while high globulins could signal chronic inflammation or immune disorders.
Can diet affect protein test results?
Yes, diet can influence protein levels. High-protein diets or malnutrition may raise or lower protein levels, respectively. Avoiding extreme dietary changes before testing helps ensure accurate results.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab. Follow up with your doctor to discuss findings and next steps.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy