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Prostate-Specific Antigen (PSA) in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of prostate-specific antigen (PSA), a protein produced primarily by the prostate gland. PSA helps doctors assess prostate health, including detecting early signs of prostate cancer or other prostate-related conditions.

Quick summary

["PSA levels can guide discussions about prostate health, but they’re not definitive on their own."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
41508-3
Short code
Gp B Strep Ag Fld Ql
Synonyms
Gp B Strep Ag Fld Ql
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why PSA Testing Matters

PSA is often used as part of a screening process for prostate cancer, especially in men at higher risk. It can also help monitor treatment progress or detect changes in prostate health over time. However, PSA alone isn’t enough to diagnose cancer—it can also rise in other conditions like benign prostatic hyperplasia (BPH) or urinary tract infections.

What to Expect During Testing

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab for analysis. Results are typically available within a few days. If your PSA level is elevated, your doctor may recommend further testing or follow-up.

Possible Causes of Elevated PSA

High PSA levels can be caused by prostate cancer, but they may also appear in conditions like an enlarged prostate, inflammation, infection, or recent ejaculation. Age, obesity, or certain medications can also affect PSA levels.

What Your Results Mean

Your PSA result is usually discussed alongside other factors, such as your age, symptoms, and family history. A doctor will interpret results in the context of your overall health. Very low PSA levels might raise concerns about prostate issues, while very high levels may warrant further investigation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

PSA Level

Frequently asked questions

What might cause my PSA level to be higher than expected?
Elevated PSA can stem from prostate cancer, but it can also be influenced by non-cancerous conditions like an enlarged prostate, infection, or recent sexual activity. Your doctor will consider all possible causes and may recommend additional tests to clarify the results.
How often should I get a PSA test?
The need for PSA testing depends on your age, health history, and risk factors. The U.S. Preventive Services Task Force recommends against routine PSA screening for men under 55, but doctors may suggest it for men at higher risk (e.g., family history of prostate cancer) or those with symptoms. Always discuss testing with your healthcare provider.
Can lifestyle changes affect PSA levels?
Yes, lifestyle factors like diet, exercise, and weight can influence PSA levels. Avoiding recent ejaculation (ideally 2–4 weeks before testing) and managing conditions like diabetes or high blood pressure may help provide more accurate results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy