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Human Papillomavirus (HPV) Genotyping by Probe-Based Nucleotide Sequence Analysis (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test identifies specific types of the human papillomavirus (HPV) present in your blood. Certain HPV types are linked to serious health risks, including certain cancers.

Quick summary

["HPV in blood may indicate long-term infection that could raise cancer risk; this test helps monitor or guide further evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
111569-0
Short code
Gp B Strep DNA BAS NAA+n-prb-NCncRng
Synonyms
Gp B Strep DNA BAS NAA+n-prb-NCncRng
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
non-probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a history of HPV-related cancers (e.g., cervical, head/neck), persistent abnormal Pap test results, or other risk factors for HPV-related diseases. It can also be used in research or specialized clinical studies.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample (serum or plasma) during a routine blood draw. Results are typically analyzed in a laboratory using advanced genetic testing techniques.

How the Test Works

The test detects specific DNA sequences from HPV types using probe-based methods. These probes match unique genetic markers of different HPV strains, allowing for precise identification.

What the Results Mean

Results show which HPV types are present in your blood. If certain high-risk HPV types are detected, further evaluation (e.g., biopsies, additional testing) may be recommended to assess cancer risk or progression.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

HPV in blood is rare but can persist long-term in some individuals. Certain HPV types (e.g., HPV-16, HPV-18) are strongly associated with cancers of the cervix, anus, penis, vulva, vagina, and head/neck. This test helps identify high-risk types for monitoring or guiding treatment decisions.

Short name

HPV Genotyping (Serum/Plasma)

Frequently asked questions

Could this test detect HPV in my saliva or urine?
No, this test specifically analyzes blood (serum/plasma). HPV detection in saliva or urine is typically done through different methods (e.g., cervical swabs, urine PCR).
What if my test shows a high-risk HPV type in my blood?
If detected, your healthcare provider will discuss next steps based on your clinical history. This may include additional imaging, biopsies, or follow-up testing to evaluate cancer risk or other health concerns.
Why would my doctor order this test if HPV is usually detected in cervical samples?
This test is used in specialized settings, such as research studies, patients with known HPV-related cancers, or those with persistent blood-based markers of HPV infection. It helps assess systemic exposure or recurrence in certain cases.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy