Skip to content

C-reactive protein (CRP) with high-sensitivity immunoassay (hs-CRP) measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises in response to inflammation, helping doctors assess low-grade inflammation or infection risk.

Quick summary

["hs-CRP helps track subtle inflammation that may not show up in other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
105800-7
Short code
Gp B Strep DNA Ct Bld Pos Qn NAA+probe
Synonyms
Gp B Strep DNA Ct Bld Pos Qn NAA+probe
Category
coagulation
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why hs-CRP Matters in Your Health

High-sensitivity CRP (hs-CRP) is a blood test that detects very small amounts of C-reactive protein, a marker of inflammation. Unlike standard CRP tests, hs-CRP can identify low-level inflammation that might not be obvious through other tests. This can be useful for monitoring conditions like cardiovascular disease risk, autoimmune disorders, or chronic infections where inflammation plays a role.

What Does hs-CRP Tell You About Your Health?

hs-CRP levels can indicate whether your body is experiencing inflammation, which is linked to many health conditions. Elevated levels may signal an increased risk of heart disease, certain cancers, or other inflammatory diseases. However, it’s important to note that hs-CRP alone doesn’t diagnose a condition—it’s often used alongside other tests and clinical findings.

How Is hs-CRP Tested?

This test involves drawing a small amount of blood from a vein. The blood is then processed to measure hs-CRP using a sensitive immunoassay method. Results are typically available within a few days and are compared to reference ranges specific to your age, sex, and health status.

What Are Common Uses for hs-CRP?

Doctors may order hs-CRP tests to evaluate cardiovascular risk, monitor chronic inflammatory conditions, assess response to treatments, or check for signs of infection or inflammation in people with no obvious symptoms. It’s also sometimes used in research or follow-up care for patients with known inflammatory diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

hs-CRP is particularly valuable for identifying individuals at higher risk of cardiovascular events, such as heart attacks or strokes, even when other risk factors like cholesterol or blood pressure are within normal ranges. It can also help guide treatment decisions for conditions like rheumatoid arthritis or inflammatory bowel disease by measuring how well inflammation is being controlled. While not a definitive test, hs-CRP provides critical information to support overall health assessments and personalized care plans.

Short name

hs-CRP

Frequently asked questions

How often should I get an hs-CRP test?
The frequency depends on your health status. Your doctor may recommend it annually or more often if you have a history of inflammation, cardiovascular disease, or other conditions that require monitoring. Regular follow-ups can help track changes in your inflammation levels over time.
What does a high hs-CRP level mean?
A high hs-CRP level suggests your body is experiencing inflammation. While it doesn’t pinpoint the cause, it may indicate an ongoing infection, autoimmune activity, or increased risk of heart disease. Your doctor will consider your overall health and other test results to interpret the results accurately.
Can lifestyle changes lower hs-CRP levels?
Yes! Reducing inflammation often involves lifestyle adjustments like improving diet (e.g., Mediterranean diet), increasing physical activity, managing stress, quitting smoking, and maintaining a healthy weight. These changes can help lower hs-CRP levels and improve overall health, even if the test result is elevated.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy