Genetic Test for Pathogenic Variants in the *GPC3* Gene (Probe-Based)
This test checks for specific changes (mutations) in the GPC3 gene, which may be linked to certain inherited conditions affecting organs like the liver, kidneys, or heart.
["It helps identify if you carry a genetic risk for rare inherited disorders that could impact your health over time."]
Key facts at a glance
- LOINC
- 106594-5
- Short code
- Gp B Strep DNA Fld Ql NAA+n-prb
- Synonyms
- Gp B Strep DNA Fld Ql NAA+n-prb
- Category
- coagulation
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- non-probe-amp-tar
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have a family history of conditions like *Glypican-3-associated tumors* (e.g., hepatocellular carcinoma) or other genetic syndromes linked to GPC3 variants. It’s also used in genetic counseling or pre-symptomatic screening for certain inherited disorders.
What to Expect Before the Test
No special preparation is needed. You’ll provide a blood sample (whole blood) for DNA extraction. The test analyzes your genetic material to detect specific mutations in the GPC3 gene.
What the Results Mean
Results will indicate whether you have the detected mutations. A positive result means you carry those variants, which may increase your risk for specific conditions. A negative result means no detectable mutations were found in this test. Consult your healthcare provider for personalized interpretation.
Common Conditions This Test Helps Diagnose
While GPC3 mutations are rare, they can be associated with conditions like *hepatocellular carcinoma* (liver cancer), *fibrolamellar carcinoma* (a rare liver tumor), or other hereditary syndromes. Early detection may guide monitoring or preventive strategies.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
GPC3 Gene Mutation Screening
Frequently asked questions
How often does this test cause false positives or negatives?
Can I get this test if I don’t have a family history of related diseases?
Will my results affect my insurance or ability to get health coverage?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy