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Urine Protein: Mass Concentration (24-Hour Collection)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein excreted in your urine over a 24-hour period. It helps assess kidney function and detect protein loss in conditions like kidney disease.

Quick summary

["A 24-hour urine protein test helps identify kidney problems by tracking protein loss in urine."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
10336-6
Short code
GP Ur-mCnc
Synonyms
GP Ur-mCnc
Category
coagulation
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Matters

Your kidneys normally filter waste and extra substances from your blood, including proteins. If they don’t work well, proteins can leak into your urine. This test helps doctors check for kidney damage or disease by measuring how much protein appears in your urine over a full day.

What to Expect Before the Test

You’ll need to collect all urine for 24 hours, starting and ending with your first morning urine. Store the samples in a refrigerator and bring the entire collection to your lab. Follow your doctor’s instructions carefully to ensure accurate results.

How the Test Works

Your urine is tested for the total protein content, which is then measured in milligrams per day. This provides a clear picture of protein loss over time, unlike a single urine dipstick test that only checks for protein at one point.

What the Results Mean

Higher-than-normal protein levels in urine may signal kidney problems, such as glomerulonephritis, diabetic nephropathy, or other conditions affecting kidney function. Your doctor will interpret the results in the context of your overall health and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

24-Hour Urine Protein

Frequently asked questions

How often should I get this test?
This test is typically ordered if you have symptoms like swelling, frequent urination, or blood in the urine. It may also be part of routine kidney checks for people with diabetes, high blood pressure, or a family history of kidney disease. Your doctor will determine how often you need it based on your health needs.
What does a normal result mean?
A normal result usually means your kidneys are filtering proteins effectively and keeping them in your bloodstream. However, even a normal result doesn’t guarantee no kidney issues—other tests may be needed for a full assessment.
Can I take medications before this test?
Some medications, like certain diuretics or NSAIDs, might affect urine protein levels. Always inform your doctor or lab technician about any medications you’re taking before the test to avoid interference with results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy