Total Protein with Albumin/Globulin Ratio (Serum)

Why This Test Matters

Total protein reflects the overall amount of proteins in your blood, including albumin and globulin. Albumin helps maintain fluid balance and supports blood vessel health, while globulins are involved in immune function and transport of substances like hormones. An abnormal ratio can signal conditions like chronic kidney disease, liver disease, or malnutrition.

How the Test Works

Blood is drawn and analyzed to measure total protein levels and the specific proportions of albumin and globulin. The results help determine if protein levels are too high or too low, or if the balance between albumin and globulin is disrupted.

Common Conditions Affecting Results

High total protein or globulin levels may occur with dehydration, multiple myeloma, or chronic infections. Low albumin levels can be linked to kidney disease, liver failure, or severe malnutrition. An abnormal ratio may indicate inflammation, autoimmune disorders, or other systemic conditions.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours if your test includes a specific protein measurement. Wear comfortable clothing for the blood draw, and inform your provider about any medications or recent illnesses.