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Cerebrospinal Fluid (CSF) Protein by Bromocresol Green Turbidimetry

Published: August 9, 2026Updated: August 16, 2026

This test measures the total protein levels in your cerebrospinal fluid (CSF), which is the fluid surrounding your brain and spinal cord. Protein levels can help diagnose conditions affecting the central nervous system.

Quick summary

["Protein levels in CSF may indicate inflammation, infection, or other neurological issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96475-9
Short code
GRAF IgG CSF Ql CBA IFA
Synonyms
GRAF IgG CSF Ql CBA IFA
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
cba-ifa
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to investigate symptoms such as headaches, neck stiffness, seizures, or neurological problems. It can also help diagnose conditions like meningitis, multiple sclerosis, or brain tumors by checking for abnormal protein buildup or patterns.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your back to collect a small amount of CSF, often done under mild sedation or local anesthesia. The procedure is quick but may cause temporary discomfort.

What the Results Mean

Normal protein levels in CSF are generally lower than in blood. Elevated protein levels may suggest inflammation, infection, or other neurological disorders. Very low levels might indicate certain genetic or metabolic conditions.

Common Conditions Affecting Results

High protein levels can be linked to conditions like multiple sclerosis, Guillain-Barré syndrome, or infections such as meningitis. Low protein levels may be seen in rare genetic disorders or certain metabolic disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Protein (BCG Turb)

Frequently asked questions

What causes abnormal protein levels in CSF?
Abnormal protein levels in CSF can result from inflammation, infections (like meningitis), autoimmune diseases (such as multiple sclerosis), or structural issues in the brain. Certain genetic or metabolic disorders may also cause low protein levels.
How often should this test be repeated?
Your provider will determine how often to repeat this test based on your symptoms, diagnosis, and treatment plan. Follow-up may be needed if initial results suggest an ongoing condition requiring monitoring.
Can diet or medications affect this test result?
Diet or over-the-counter medications typically do not affect CSF protein levels. However, certain medications (like steroids) or conditions (such as severe dehydration) might indirectly influence results, so always inform your healthcare provider of all medications or supplements you take.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy