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Serum/plasma mass concentration of total protein

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps assess overall protein status and kidney function.

Quick summary

["Total protein levels can signal kidney issues or nutritional problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
89659-7
Short code
Gram Stn Implnt dev
Synonyms
Gram Stn Implnt dev
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
gram-stain
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for conditions like kidney disease, liver problems, malnutrition, or dehydration. It can also help monitor protein loss due to conditions like nephrotic syndrome or certain cancers.

What Does a Low or High Result Mean?

Low total protein levels might indicate malnutrition, liver disease, or kidney problems, while high levels could suggest dehydration, inflammation, or conditions like multiple myeloma.

How Is This Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it is analyzed to measure total protein content using standard laboratory techniques.

What Are Common Causes of Abnormal Results?

Abnormal results can stem from chronic kidney disease, liver disease, infections, severe burns, or certain medications. Genetic factors or rapid weight loss can also play a role.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What if I Have Questions About My Results?
If your results are outside the expected range, discuss them with your healthcare provider. They can help explain what your results mean in the context of your health and any treatments you’re receiving.
How Often Should This Test Be Done?
The frequency depends on your health condition. Some people need this test regularly (e.g., monthly or quarterly) if they have chronic kidney or liver disease, while others may only need it once or twice a year.
Can I Avoid This Test?
No, this test is essential for monitoring certain health conditions. Skipping it could delay diagnosis or treatment for serious issues like kidney disease or protein loss.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy