Skip to content

Serum or plasma total protein concentration (mass concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins. Proteins help maintain fluid balance, support immune function, and transport nutrients.

Quick summary

["Your blood protein levels can indicate overall health, hydration status, or potential medical conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
88632-5
Short code
Gram Stn Lower resp
Synonyms
Gram Stn Lower resp
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
gram-stain
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Doctors may order a total protein test to check for conditions like dehydration, kidney disease, liver problems, or certain infections. It can also help diagnose or monitor diseases such as multiple myeloma or inflammatory disorders.

What to Expect Before the Test

You may be asked to fast for a few hours before the test, depending on your doctor’s instructions. Bring any medications or supplements you’re taking, as they can sometimes affect results. Avoid strenuous activity or excessive alcohol before the draw.

During the Test

A healthcare professional will draw blood from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause discomfort. The blood sample is then sent to a lab for analysis.

What the Results Mean

Results are typically reported in grams per deciliter (g/dL). Low protein levels might suggest malnutrition, kidney issues, or liver disease, while very high levels could indicate conditions like multiple myeloma or severe dehydration.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes low total protein levels?
Low protein levels can result from conditions like kidney disease, liver problems, severe malnutrition, or chronic infections. It may also indicate excessive protein loss through urine (e.g., nephrotic syndrome) or rapid fluid loss.
What causes high total protein levels?
High protein levels can occur with conditions like multiple myeloma (a blood cancer), severe dehydration, or chronic inflammation. Rarely, it may be due to certain medications or lab artifacts.
How often should I get this test?
Your doctor will determine how often you need this test based on your health status, symptoms, and ongoing treatments. Regular monitoring may be recommended if you have chronic conditions like kidney or liver disease.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy