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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and globulins. Proteins are essential for maintaining fluid balance, supporting immune function, and transporting nutrients.

Quick summary

["Your blood protein levels help assess overall health and detect conditions like malnutrition, kidney disease, or liver problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
87967-6
Short code
Gram Stn Mar
Synonyms
Gram Stn Mar
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
gram-stain
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It Matters in Your Health

Blood proteins play critical roles in your body. They help regulate fluid balance, support immune defense, and transport important substances like hormones and vitamins. Low or high protein levels can signal underlying health issues.

What to Expect During the Test

A simple blood draw is used to collect serum for this test. No special preparation is needed, but fasting may be required depending on your healthcare provider’s instructions.

Common Conditions Affecting Results

Low protein levels might indicate conditions like malnutrition, kidney disease, or severe infections. High levels could suggest liver disease, dehydration, or certain inflammatory conditions.

Factors That Can Influence Results

Diet, hydration status, and certain medications can affect protein levels. Recent illness, pregnancy, or chronic conditions may also impact your test results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Serum Protein

Frequently asked questions

What does a low or high total protein result mean?
A low total protein result may signal conditions like protein-losing disorders, malnutrition, or kidney or liver disease. A high result could indicate dehydration, liver disease, or certain inflammatory or infectious processes. Your doctor will review your full medical picture to interpret results accurately.
How often should I get this test?
Your doctor will determine how often you need this test based on your health status, symptoms, and any ongoing conditions. Regular monitoring may be recommended if you have chronic illnesses like kidney disease or liver problems.
Can I eat or drink before this test?
Follow your doctor’s instructions regarding fasting or dietary restrictions. Some tests require fasting, while others do not. Always confirm with your healthcare provider before preparing for the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy