Skip to content

Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and other proteins like globulins.

Quick summary

["Your blood protein levels help assess overall health and detect conditions like malnutrition or kidney disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
32026-7
Short code
Gram Stn Nose
Synonyms
Gram Stn Nose
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
gram-stain
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Blood Protein Testing Used For?

Blood protein tests are commonly used to diagnose and monitor conditions affecting protein production, such as liver disease, kidney problems, or malnutrition. They can also help identify signs of inflammation or infection by checking for abnormal protein levels, including albumin, which supports fluid balance in your body.

How Is This Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate serum (the liquid part after clotting) for testing. The test measures the combined weight of all proteins in this serum.

What Might Affect Your Results?

Several factors can influence blood protein levels, including diet (especially protein intake), certain medications, liver or kidney disease, infections, or chronic conditions like diabetes. Recent blood loss, dehydration, or pregnancy may also impact results.

Common Conditions Monitored With This Test

Low protein levels may signal malnutrition, liver disease (like cirrhosis), or kidney disease. High levels could indicate dehydration, multiple myeloma (a blood cancer), or certain inflammatory conditions. Albumin, a key protein, is often checked alongside total protein to assess fluid balance and organ function.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

Why did my doctor request this test?
Your doctor may recommend a total protein test if you have symptoms like unexplained weight loss, swelling, fatigue, or signs of organ issues (like liver or kidney problems). It can also help check for conditions like malnutrition, infections, or blood disorders.
What are the typical reference ranges for this test?
Reference ranges vary by lab and individual health, but generally, total protein levels in serum range from about 6.4 to 8.3 grams per deciliter (g/dL). Your actual results will be compared to your specific lab’s standards and your health status.
How long will it take to get my results?
Results are typically available within 1 to 3 business days, depending on your lab and insurance processing times. Follow-up with your healthcare provider if you have questions about your results.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy