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Total Protein in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins.

Quick summary

["Your blood protein levels help your body stay healthy by maintaining fluid balance and supporting immune function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14360-2
Short code
Gram Stn Plr
Synonyms
Gram Stn Plr
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
gram-stain
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why It Matters in Your Health

Protein is essential for many bodily functions, including transporting nutrients, fighting infections, and repairing tissues. Low protein levels might suggest conditions like kidney disease or malnutrition, while very high levels could indicate conditions like multiple myeloma or severe dehydration.

What to Expect During the Test

A simple blood draw is used to collect a small sample of your blood, which is then sent to a lab for analysis. No special preparation is usually needed, but fasting may be advised depending on your doctor’s instructions.

Common Causes of Abnormal Results

Low protein levels can result from conditions like kidney disease, liver problems, or poor nutrition. High protein levels may be linked to dehydration, certain cancers, or inflammatory diseases. Your doctor will discuss these findings with you based on your medical history and other test results.

How Your Results Are Interpreted

Your doctor will compare your results to standard ranges and consider your overall health. While reference ranges can vary slightly by lab, they provide a general guideline for what is considered normal.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: When to Pay Attention

Short name

Total Protein

Frequently asked questions

What does my total protein level tell me about my health?
Your total protein level can give clues about your overall health, especially if combined with other tests. For example, low levels might raise concerns about kidney or liver function, while high levels could signal dehydration or other underlying conditions. Always discuss your results with your healthcare provider for personalized insights.
How often should I get this test?
The frequency depends on your health status and any conditions your doctor monitors. Some people may need this test annually or more often if they have chronic illnesses like kidney disease or liver problems. Your doctor will determine the best schedule for you.
Can diet affect my protein test results?
Diet can influence protein levels indirectly—for example, eating too little protein may lower your total protein, while excessive intake might raise it. However, your doctor may ask you to follow specific instructions (like fasting) before the test to get accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy