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Total Serum Protein (by Electrophoresis)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your serum, which includes albumin and other proteins like globulins. Proteins are important for maintaining fluid balance, supporting immunity, and transporting nutrients.

Quick summary

["Your blood protein levels help doctors assess overall health and detect conditions like kidney disease or malnutrition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
664-3
Short code
Gram Stn Spec
Synonyms
Gram Stn Spec
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
gram-stain
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test uses electrophoresis to separate and quantify different protein types in your serum. This method helps identify abnormalities in protein distribution, which can signal underlying health issues.

Why Might You Need This Test?

Your doctor may order this test to evaluate kidney function, check for protein-losing conditions, monitor liver disease, or assess nutritional status. It’s also used in screening for conditions like multiple myeloma or autoimmune disorders.

How Is the Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The serum is then separated and analyzed using electrophoresis to measure total protein concentration.

What Are Common Results and Their Meanings?

Higher-than-expected protein levels might indicate dehydration, inflammation, or certain cancers. Lower-than-expected levels could suggest malnutrition, liver disease, or kidney problems. Always discuss results with your healthcare provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: How Does This Test Help Doctors?

Short name

Total Protein

Frequently asked questions

How long does it take to get my results back?
Results are typically available within 24 to 48 hours, depending on your lab’s processing time. Your doctor will explain the results in detail during your follow-up visit.
Can I eat or drink anything before this test?
No special preparation is needed for this test. However, if your doctor has specific instructions (like fasting), follow them to ensure accurate results.
What if my protein levels are outside the expected range?
If your results are abnormal, your doctor may recommend further testing or treatments to address potential conditions like dehydration, kidney disease, or nutritional deficiencies. Follow-up visits will help monitor your health closely.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy