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Granulocyte Count in Cerebrospinal Fluid (Manual Count)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of white blood cells called granulocytes in your cerebrospinal fluid (CSF), which is the fluid surrounding your brain and spinal cord. It helps assess for infections, inflammation, or other conditions affecting these cells.

Quick summary

["Granulocyte levels in CSF can indicate infections or inflammatory processes in the central nervous system."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
12244-0
Short code
Granulocytes NFr CSF Manual
Synonyms
Granulocytes NFr CSF Manual
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like severe headaches, neck stiffness, fever, or neurological issues that suggest possible infections (e.g., meningitis), autoimmune diseases, or other conditions affecting the brain or spinal cord. It’s often performed alongside other tests like a lumbar puncture to collect CSF for analysis.

How the Test Works

A small sample of CSF is collected through a procedure called a lumbar puncture (spinal tap). The sample is then examined under a microscope by a trained professional to count the granulocyte cells manually. This method provides detailed information about cell types and their presence in the fluid.

What to Expect Before the Test

You may need to fast for a few hours before the test, depending on your doctor’s instructions. Wear comfortable clothing with loose-fitting bottoms, as you’ll need to bend over slightly during the procedure. Inform your doctor about any medications you’re taking, especially blood thinners, to avoid unnecessary risks.

What to Expect During the Test

The procedure involves inserting a needle into your lower back to collect CSF. You’ll feel a brief pinch, but the process is usually quick. You may experience mild discomfort or pressure, but it’s temporary. Afterward, you’ll rest for a short time to avoid headaches.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated granulocyte counts in CSF may suggest bacterial infections (e.g., bacterial meningitis), certain inflammatory conditions, or other immune responses. Low or normal counts could indicate viral infections, non-infectious conditions, or no significant pathology. Your doctor will interpret results in the context of your symptoms and overall health.

Short name

CSF Granulocyte Count

Frequently asked questions

How often is this test repeated?
The frequency depends on your symptoms and diagnosis. If your doctor suspects a persistent or recurring issue, they may order this test again after a few days or weeks to monitor changes.
What are common causes of abnormal granulocyte counts in CSF?
Abnormal granulocyte counts can result from infections (like bacterial or fungal meningitis), autoimmune diseases (e.g., multiple sclerosis), trauma to the spine or brain, or certain medications. Always discuss your symptoms and medical history with your doctor for personalized insights.
Can I eat or drink before this test?
Typically, you should avoid food for a few hours before the test, but drink plenty of water unless instructed otherwise. Follow your doctor’s specific guidelines to ensure accuracy.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy