Granulocyte Count in Cerebrospinal Fluid (Manual Count)
This test measures the number of white blood cells called granulocytes in your cerebrospinal fluid (CSF), which is the fluid surrounding your brain and spinal cord. It helps assess for infections, inflammation, or other conditions affecting these cells.
["Granulocyte levels in CSF can indicate infections or inflammatory processes in the central nervous system."]
Key facts at a glance
- LOINC
- 12244-0
- Short code
- Granulocytes NFr CSF Manual
- Synonyms
- Granulocytes NFr CSF Manual
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- manual-count
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may order this test if you have symptoms like severe headaches, neck stiffness, fever, or neurological issues that suggest possible infections (e.g., meningitis), autoimmune diseases, or other conditions affecting the brain or spinal cord. It’s often performed alongside other tests like a lumbar puncture to collect CSF for analysis.
How the Test Works
A small sample of CSF is collected through a procedure called a lumbar puncture (spinal tap). The sample is then examined under a microscope by a trained professional to count the granulocyte cells manually. This method provides detailed information about cell types and their presence in the fluid.
What to Expect Before the Test
You may need to fast for a few hours before the test, depending on your doctor’s instructions. Wear comfortable clothing with loose-fitting bottoms, as you’ll need to bend over slightly during the procedure. Inform your doctor about any medications you’re taking, especially blood thinners, to avoid unnecessary risks.
What to Expect During the Test
The procedure involves inserting a needle into your lower back to collect CSF. You’ll feel a brief pinch, but the process is usually quick. You may experience mild discomfort or pressure, but it’s temporary. Afterward, you’ll rest for a short time to avoid headaches.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated granulocyte counts in CSF may suggest bacterial infections (e.g., bacterial meningitis), certain inflammatory conditions, or other immune responses. Low or normal counts could indicate viral infections, non-infectious conditions, or no significant pathology. Your doctor will interpret results in the context of your symptoms and overall health.
Short name
CSF Granulocyte Count
Frequently asked questions
How often is this test repeated?
What are common causes of abnormal granulocyte counts in CSF?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy