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Absolute Neutrophil Count (ANC) or Differential Neutrophil Count (Manual)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of neutrophils, a type of white blood cell, in your blood. Neutrophils help fight infections and inflammation.

Quick summary

["Understanding your neutrophil count helps doctors assess infection risk or immune response."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
71608-4
Short code
Granulocytes NFr.DF Plr Manual
Synonyms
Granulocytes NFr.DF Plr Manual
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to check for infections, blood disorders (like leukemia), or immune system issues. It’s also used to monitor conditions like chronic inflammation or after treatments that affect white blood cells.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm or hand to draw blood. If you’re nervous, let your doctor or nurse know—you can ask about pain relief options.

What the Test Results Mean

Results show the absolute number of neutrophils per microliter of blood. Low counts may indicate infection, immune problems, or bone marrow disorders. High counts could signal infection, inflammation, or stress.

Common Conditions Affecting Neutrophils

Neutrophil counts can drop due to infections (like pneumonia or urinary tract infections), autoimmune diseases, or medications. They may rise with bacterial infections, severe stress, or certain cancers.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: Neutrophils are the body’s first responders to bacterial infections. Abnormally low counts (neutropenia) increase infection risk, while elevated counts (neutrophilia) may signal inflammation or infection. This test is critical for diagnosing and managing blood disorders, infections, or immune-related conditions.

Short name

Neutrophil Count

Frequently asked questions

What causes a low neutrophil count?
Low neutrophil counts can result from infections, certain medications (like chemotherapy), autoimmune diseases, or genetic disorders. Your doctor may also check for bone marrow issues if the problem persists.
How long does it take to get test results?
Results are typically available within 1–2 business days, depending on your lab. Your doctor will discuss them with you during your follow-up visit.
Can I eat or drink before this test?
Yes, you can eat and drink normally. This test only requires blood, so fasting isn’t needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy