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Absolute Neutrophil Count (ANC) – Manual Differential

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of neutrophils, a type of white blood cell, in your blood. Neutrophils help fight infections.

Quick summary

["Neutrophils are key defenders against bacterial infections; low counts may signal immune issues or infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
71617-5
Short code
Granulocytes NFr.DF Snv Manual
Synonyms
Granulocytes NFr.DF Snv Manual
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why This Test Matters

Your doctor may order this test to check if your immune system is working properly, especially if you’re prone to infections or have certain blood disorders. Neutrophils are particularly important in fighting bacterial infections, so their count can help identify problems like severe neutropenia or overactive immune responses.

What to Expect Before the Test

No special preparation is needed. A simple blood draw from a vein in your arm is all that’s required. The manual differential process involves examining your blood under a microscope by a trained lab technician.

How the Test Works

Blood is collected and examined under a microscope. A technician counts the number of neutrophils (and other white blood cells) in a specific volume of blood. This count is expressed as the number of neutrophils per microliter (µL) of blood.

What the Results Mean

Results are typically reported as an absolute count (e.g., number of neutrophils per µL). Low counts may indicate conditions like chemotherapy side effects, autoimmune diseases, or infections. High counts can suggest inflammation, infections, or other medical conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

ANC (Manual Diff)

Frequently asked questions

What does a low neutrophil count mean?
A low neutrophil count (below normal levels) can mean your body has trouble fighting off infections, especially bacterial ones. This may happen due to medications, certain diseases, or genetic conditions. Your doctor will discuss further tests or treatments if needed.
How often should I get this test?
The frequency depends on your health condition and treatment plan. If you have a chronic illness or are undergoing treatment (like chemotherapy), your doctor may recommend regular monitoring. Otherwise, this test is usually done only when symptoms or concerns suggest it’s needed.
Can I eat or drink before this test?
You can eat and drink normally before this test. No fasting is required, as it’s a simple blood draw without affecting neutrophil counts.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy