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Granulocyte Count (Manual Differential Blood Count)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number and types of white blood cells called granulocytes, which include neutrophils, eosinophils, and basophils, in your blood. It helps assess immune function and identify infections or inflammatory conditions.

Quick summary

["Granulocyte counts help diagnose and guide treatment for infections, allergies, or immune disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14377-6
Short code
Granulocytes NFr Smn Manual
Synonyms
Granulocytes NFr Smn Manual
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to evaluate your immune system, check for infections (such as bacterial or fungal), or monitor conditions like chronic inflammation, autoimmune diseases, or blood disorders. It can also help diagnose certain types of leukemia or other blood cancers.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into a vein (usually in your arm) to draw blood. The process takes a few minutes, and you may feel a brief pinch. If you’re nervous, let your healthcare provider know.

What the Test Results Mean

Results show the percentage of granulocytes (neutrophils, eosinophils, and basophils) among all white blood cells. Abnormal counts may indicate infections, allergies, or immune system issues. Your doctor will interpret results in the context of your overall health.

Common Conditions This Test Helps Diagnose

High granulocyte counts might suggest infections, inflammation, or stress responses. Low counts could indicate immune deficiencies, certain cancers, or medications that suppress white blood cells. Always discuss results with your doctor.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Granulocyte Differential

Frequently asked questions

How long does it take to get my granulocyte test results?
Results are typically available within 1 to 3 business days, depending on your lab. Your healthcare provider will share them with you during your follow-up visit.
Can I eat or drink before this test?
No special diet or fasting is required for this test. However, if you’re taking blood thinners or have a history of clotting issues, let your doctor know before the procedure.
What does it mean if my granulocyte count is very high or very low?
Very high granulocyte counts may signal infections, severe inflammation, or stress (e.g., from illness or surgery). Very low counts could mean immune problems, certain medications, or blood disorders. Your doctor will explain what your specific results mean for you.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy