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Glutamate Oxaloacetate Transaminase (GOT) / Aspartate Aminotransferase (AST)

Published: August 9, 2026Updated: August 16, 2026

This blood test measures the activity of an enzyme called aspartate aminotransferase (AST), which helps assess liver and heart health. AST is found in high levels in liver cells and some heart tissue.

Quick summary

["AST helps detect liver damage or heart issues by measuring enzyme leakage into the bloodstream."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
94413-2
Short code
GRIK4 c.83-10039T>C Geno Bld/T
Synonyms
GRIK4 c.83-10039T>C Geno Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is AST Used For?

AST is primarily used to evaluate liver function and diagnose conditions like hepatitis, alcohol-related liver damage, or cirrhosis. It can also help identify heart problems, such as heart attacks, by detecting enzyme release from damaged heart muscle.

How Is AST Tested?

A small blood sample is drawn from your arm. The sample is sent to a lab where AST activity is measured using a specialized test that detects enzyme levels in your serum or plasma.

When Might You Need an AST Test?

Your doctor may order an AST test if you have symptoms like jaundice (yellowing skin), fatigue, abdominal pain, or if you have risk factors for liver disease (e.g., heavy alcohol use, viral hepatitis). It may also be checked after a heart attack or other conditions that could damage liver or heart tissue.

What Could Abnormal Results Mean?

Elevated AST levels may indicate liver damage, inflammation, or disease. Very high levels could signal severe liver injury or heart issues. Low levels alone usually aren’t concerning unless other tests or symptoms suggest a deficiency.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: AST plays a key role in liver metabolism and energy production. Elevated AST is often a sensitive marker for liver cell damage, helping doctors monitor chronic liver conditions, screen for acute liver injury, or guide treatment decisions. It can also be used alongside other tests to differentiate between liver and heart-related enzyme leaks.

Short name

AST Level

Frequently asked questions

Why did my doctor order an AST test?
Your doctor may have ordered it to check for liver problems (like hepatitis or fatty liver), monitor a known liver condition, or assess potential heart damage (e.g., after a heart attack). It could also be part of a routine health check or screening if you have risk factors.
What do my AST results mean if they’re high?
High AST levels often suggest liver damage or inflammation, but they can also appear in heart conditions. Your doctor will review your results alongside other tests, symptoms, and medical history to determine the cause. Treatment may include lifestyle changes, medications, or further testing.
Can I lower my AST levels naturally?
While AST levels are influenced by liver health, avoiding alcohol, maintaining a balanced diet, staying hydrated, and managing conditions like diabetes or obesity can support liver function. Always follow your doctor’s advice for personalized care.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy