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Glucose [Mass/volume] in Cerebrospinal Fluid

Published: August 9, 2026Updated: August 16, 2026

Measures the amount of glucose in cerebrospinal fluid, the fluid surrounding the brain and spinal cord. This test is usually performed with other CSF tests.

Quick summary

["CSF glucose helps clinicians evaluate conditions that may affect the brain and spinal cord."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2327-5
Short code
GRP CSF-mCnc
Synonyms
GRP CSF-mCnc
Category
liver
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What is this test?

Cerebrospinal fluid (CSF) glucose test measures the concentration of glucose in the fluid around the brain and spinal cord. It is usually ordered when symptoms suggest meningitis, encephalitis, or another condition affecting the central nervous system.

Why might I need this test?

The test can help clinicians evaluate suspected infection or inflammation involving the brain and spinal cord. It is generally interpreted with the rest of the CSF analysis, including white blood cells, protein, and opening pressure, as well as your blood glucose level.

How is the test performed?

A clinician collects a small amount of CSF with a lumbar puncture, also called a spinal tap. The fluid is sent to a laboratory, where its glucose concentration is measured.

How do I prepare for the test?

Follow your clinician's instructions about the procedure, including any restrictions on food or drink. Tell the clinician if you have a bleeding disorder, take blood thinners, or have had back surgery, because these factors may affect the safety of a lumbar puncture.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A low CSF glucose level may occur with certain infections, inflammation, or other conditions affecting the central nervous system. A high level may reflect elevated blood glucose or another cause and should be interpreted alongside blood glucose and other test results. This measurement alone does not establish a diagnosis.

Short name

CSF glucose

Frequently asked questions

Is a lumbar puncture painful?
A lumbar puncture may cause brief pressure or discomfort, but local anesthetic is usually used to reduce pain. Tell the clinician if you have severe back pain, numbness, or weakness afterward.
Does fasting affect the test?
Fasting is not usually required for the CSF sample itself, but your blood glucose may need to be measured at the same time for accurate interpretation. Follow any specific instructions from your clinician.
Can I get the results from a routine blood test?
No. A separate sample of cerebrospinal fluid is needed, so the test must be performed during a lumbar puncture.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy