Alpha-1 Antitrypsin (A1AT) Serum Immunoassay (Quantitative)
This test measures the level of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs from damage caused by enzymes released during inflammation.
["A1AT helps prevent lung disease; low levels may indicate genetic risk or lung/lung-related conditions."]
Key facts at a glance
- LOINC
- 89509-4
- Short code
- GT1a Gangl IgG+IgM Ser Ql Line blot
- Synonyms
- GT1a Gangl IgG+IgM Ser Ql Line blot
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- line-blot
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may order this test if you have or are at risk for conditions like chronic obstructive pulmonary disease (COPD), emphysema, or other lung diseases. It may also be used to check for genetic mutations linked to A1AT deficiency, which can affect both lungs and liver.
What to Expect During the Test
A blood sample is drawn from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause discomfort. The sample is sent to a lab for testing using an immunoassay method to measure your A1AT protein levels.
Preparation and Timing
No special preparation is needed for this test. You can eat and drink normally before your appointment. Results may take several days to a week, depending on lab processing times.
Common Conditions Monitored
Low A1AT levels are often associated with conditions like alpha-1 antitrypsin deficiency, which can lead to lung diseases (e.g., emphysema) or liver problems. High levels may rarely indicate other health concerns.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test plays a critical role in diagnosing genetic disorders affecting lung function and liver health. Early detection can help manage symptoms and prevent complications, particularly in individuals with a family history of A1AT deficiency.
Short name
A1AT Level
Frequently asked questions
What does an abnormal A1AT level mean?
How often should I get this test?
Can diet or supplements affect A1AT levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy