Ganglioside GM1 (qualitative) by Line Blot Assay
This test detects specific ganglioside molecules, which are complex lipids found in nerve cells. It may be used to help diagnose certain neurological conditions.
This test helps identify rare genetic or metabolic disorders affecting nerve function.
Key facts at a glance
- LOINC
- 82413-6
- Short code
- GT1a Gangl IgM Ser Ql Line blot
- Synonyms
- GT1a Gangl IgM Ser Ql Line blot
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- line-blot
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test looks for the presence of ganglioside GM1, a type of lipid that plays a role in nerve cell function. Gangliosides are part of the cell membrane in neurons and can be altered in certain neurological diseases. This specific test uses a line blot assay to detect these molecules qualitatively, meaning it tells you whether the substance is present or not, rather than measuring an exact amount.
Why It Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like muscle weakness, developmental delays, or neurological issues that suggest a ganglioside-related disorder. It could also be part of a broader evaluation for inherited metabolic diseases or rare genetic conditions affecting the nervous system.
Sample Collection and Preparation
This test typically requires a sample of whole blood (red blood cells, plasma, or serum). Blood is drawn from a vein in your arm. The sample is then processed and analyzed in a laboratory using a specialized line blot assay to detect ganglioside GM1.
What to Expect Before the Test
No special preparation is usually needed for this test. You may be asked to fast for a few hours before the blood draw if your provider recommends it, but this is not always the case for qualitative tests like this one. Wear comfortable clothing and plan to rest after the blood draw.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Ganglioside GM1 abnormalities are linked to certain neurological disorders, including GM1 Gangliosidosis, a rare genetic disorder that affects how cells process certain fats. Detecting GM1 can help confirm a diagnosis and guide treatment options. Early identification can be crucial for managing symptoms and planning interventions.
Short name
GM1 Ganglioside Screening (Qualitative)
Frequently asked questions
What does a positive result mean?
What does a negative result mean?
How often is this test repeated?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy