Guanosine/Creatinine Ratio, Urine
A urine test that compares the amount of guanosine, a purine breakdown product, with the amount of creatinine in the same urine sample.
["This ratio helps evaluate purine metabolism while reducing the effect of differences in urine concentration."]
Key facts at a glance
- LOINC
- 78691-3
- Short code
- Guanosine/Creat Ur-sRto
- Synonyms
- Guanosine/Creat Ur-sRto
- Category
- kidney
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test measures guanosine relative to creatinine in urine. Guanosine is part of the purine pathway, and creatinine is a waste product commonly used to help account for how concentrated a urine sample is.
Why might I need this test?
A clinician may order this test when evaluating unusual results on a urine purine test or when investigating a possible inherited disorder of purine metabolism. It can also be used alongside other urine and blood tests to interpret guanosine excretion.
How is the test performed?
A urine specimen is collected according to the laboratory’s instructions. The laboratory measures guanosine and creatinine in the sample and calculates their ratio. The result may come from a single urine collection or a timed collection, depending on the order.
How do I prepare for the test?
Follow the laboratory’s directions for urine collection, including whether a first-morning, spot, or timed sample is needed. Tell your clinician about medicines, vitamin supplements, or dietary changes that could affect the result, and do not stop prescribed medicines unless instructed.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
An elevated ratio may indicate increased guanosine excretion or reduced urinary creatinine, so urine concentration, kidney function, medications, and diet may affect the result. Abnormal findings may be associated with disorders of purine metabolism, but this test usually requires interpretation alongside other laboratory results and symptoms.
Short name
Urine Guanosine/Creatinine Ratio
Frequently asked questions
Is this the same as a routine urine creatinine test?
Why is creatinine included in the result?
Does an abnormal result diagnose a specific condition?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy