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Urine Protein-to-Creatinine Ratio (24-hour collection)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein and creatinine in your urine over a full day to help check for kidney problems, such as kidney disease or excessive protein loss.

Quick summary

["Assesses kidney function and protein loss in urine over 24 hours."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
87142-6
Short code
Guided UE CVC w port exch
Synonyms
Guided UE CVC w port exch
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
imaging-modality
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like swelling, frequent urination, or unexplained weight changes. It’s also used to monitor kidney health in people with diabetes, high blood pressure, or a family history of kidney disease.

How the Test Works

You’ll collect all your urine for 24 hours, typically starting and ending at the same time each day. The urine is stored in a special container, and the lab analyzes the protein and creatinine levels to calculate the ratio.

What to Expect

You’ll receive instructions on how to properly collect your urine sample. Some people may need to wear a collection bag or use a container to hold their urine. Avoid certain foods or medications that could interfere with the test results.

Possible Results and Interpretation

Higher-than-normal protein levels in urine may indicate kidney damage or disease. Lower-than-normal results might suggest dehydration or other conditions. Your doctor will interpret the results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: This test is critical for diagnosing and monitoring kidney disease, detecting proteinuria (protein in urine), and assessing long-term kidney damage. Elevated ratios may signal conditions like glomerulonephritis, diabetic nephropathy, or other kidney disorders.

Short name

24-Hour Urine Protein-to-Creatinine Ratio

Frequently asked questions

What does a high urine protein-to-creatinine ratio mean?
A high ratio may indicate kidney problems, such as kidney disease or damage to the filtering units in your kidneys. It could also suggest conditions like diabetes or high blood pressure affecting kidney function.
How often should I get this test?
Your doctor will determine how often you need this test based on your health history, symptoms, and other medical conditions. Some people may need it yearly, while others may require more frequent checks.
Can I eat or drink anything before the test?
Follow your doctor’s instructions carefully. Typically, you’ll need to collect all urine for 24 hours, but avoid certain foods or medications that might affect the results, such as high-protein foods or some pain relievers.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy