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Cerebrospinal Fluid Total Protein by Electrophoresis

Published: August 9, 2026Updated: August 16, 2026

This test measures the total protein levels in your cerebrospinal fluid (CSF) using electrophoresis, a method that separates proteins based on size and charge. It helps identify patterns of protein distribution that may indicate underlying conditions affecting your nervous system.

Quick summary

["This test helps diagnose or monitor conditions like infections, inflammation, or blood leaks in the brain/spinal cord."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
23950-9
Short code
HAdV Ab Titr CSF CF
Synonyms
HAdV Ab Titr CSF CF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
comp-fix
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like headaches, neck stiffness, vision changes, or neurological issues (e.g., numbness, weakness). It’s also used in diagnosing conditions such as meningitis, multiple sclerosis, or tumors in the central nervous system.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your lumbar spine (lower back) to collect CSF. The procedure is quick but may cause mild discomfort. You’ll lie on your side with your knees bent.

What the Results Mean

Normal results show a balanced protein distribution across different protein fractions. Abnormal patterns (e.g., high albumin in the white matter) may suggest conditions like Guillain-Barré syndrome, subarachnoid hemorrhage, or infections.

Common Conditions Affecting Results

Elevated total protein can occur with infections (e.g., bacterial or viral meningitis), inflammatory diseases (e.g., multiple sclerosis), or blood leaks into the CSF. Low protein levels may indicate congenital disorders or rare metabolic conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is critical for diagnosing conditions that alter protein composition in CSF, such as demyelinating diseases, infections, or neoplastic processes. It complements other tests (e.g., CSF cell count, MRI) to guide treatment decisions.

Short name

CSF Protein Electrophoresis

Frequently asked questions

How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing. Follow-up with your provider will help interpret findings in context.
Can I drink alcohol before this test?
No alcohol for 24 hours before the test, as it may affect protein levels in CSF. Avoid caffeine or heavy exercise the day of the procedure.
Does this test require fasting?
No fasting is required. However, inform your provider about any medications or supplements you’re taking, as they may influence results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy