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Haptoglobin in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of haptoglobin, a protein in your blood that helps protect against bleeding and infection by binding to free hemoglobin released during red blood cell destruction.

Quick summary

["Haptoglobin helps identify conditions affecting red blood cells or blood clotting."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
40717-1
Short code
Haptoglob SerPl Ql
Synonyms
Haptoglob SerPl Ql
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Haptoglobin?

Haptoglobin is a protein produced by the liver that binds to hemoglobin (the oxygen-carrying part of red blood cells) when red blood cells break down. This binding prevents hemoglobin from entering tissues, which could otherwise cause damage or bleeding. Low levels may suggest red blood cell destruction or other blood-related issues.

Why Might You Need This Test?

Doctors may order a haptoglobin test to investigate symptoms like anemia, unexplained bleeding, or signs of red blood cell breakdown (hemolysis). It can also help diagnose conditions such as hemolytic anemia, liver disease, or certain infections.

When Could Results Be Abnormal?

Results may be low if you have hemolytic anemia (where red blood cells break down too quickly), severe infections, liver disease, or certain blood disorders. Results may be high in rare cases of acute inflammation or certain genetic conditions.

What Does a Low Level Mean?

A low haptoglobin level often signals red blood cell destruction, which can occur in conditions like sickle cell disease, autoimmune hemolytic anemia, or exposure to certain medications or toxins.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: serum

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Haptoglobin

Frequently asked questions

What causes low haptoglobin levels?
Low haptoglobin levels are most commonly linked to hemolytic anemia (where red blood cells break down faster than normal), but they can also result from severe infections, liver disease, or certain medications.
What if my haptoglobin is very low?
A very low result may indicate a serious condition like severe hemolysis, which requires further testing (such as blood counts or genetic evaluation) to determine the exact cause and guide treatment.
Can haptoglobin levels change with diet?
Haptoglobin levels are primarily influenced by health conditions affecting red blood cells or liver function, not diet. However, maintaining a balanced diet can support overall blood health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy