Hyaluronic Acid, Serum or Plasma — Mass Concentration

What Is Being Measured

Hyaluronic acid (also called hyaluronan) is a large carbohydrate molecule that helps lubricate joints, cushion tissues, and support skin and connective tissue. It is produced throughout the body and cleared mainly by the liver. This test estimates how much hyaluronic acid is present in the liquid portion of blood (serum or plasma) using a mass concentration measurement.

Why Your Clinician May Order It

Hyaluronic acid is sometimes measured as a marker of liver fibrosis (scarring) or to help assess certain joint and connective tissue conditions. It is not a routine screening test and is usually ordered when other liver or tissue evaluations suggest a need for additional information.

How the Sample Is Collected

A blood sample is drawn from a vein, typically in your arm, and the serum or plasma is separated for testing. No special preparation is usually required, but follow any instructions your clinician or laboratory provides.

What the Results Mean

Higher hyaluronic acid levels may be seen with liver scarring, inflammation, or certain tissue disorders, while normal levels vary by age and laboratory method. Because this is a specialized test, your clinician will interpret the result in the context of your symptoms, other liver tests, and imaging rather than relying on this value alone.