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Immunoglobulin G (IgG) in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Immunoglobulin G (IgG), the most common type of antibody in your blood. IgG helps fight infections and is important for long-term immunity.

Quick summary

["IgG levels help assess immune function and detect potential deficiencies or excesses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
97980-7
Short code
Hazelnut (rCor a) 14 IgG4-mCnc
Synonyms
Hazelnut (rCor a) 14 IgG4-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does IgG Measure?

IgG is a type of antibody produced by your immune system to protect against bacteria and viruses. It plays a key role in defending against infections and helping your body remember past illnesses. This test specifically measures the concentration of IgG in your blood, which can vary depending on your health status, immune response, and other factors.

Why Might You Need This Test?

Doctors may order an IgG test to evaluate immune function, diagnose conditions like immunodeficiency, monitor treatment for autoimmune diseases, or check for infections. It can also be used in newborns to assess early immune development or in individuals with chronic illnesses.

Common Reasons for Testing

Common reasons include diagnosing conditions like common variable immunodeficiency (CVID), checking immune response after vaccination, or monitoring immune-related diseases. It may also be used in research or specialized clinical settings to study antibody levels.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it involves drawing blood. Wear comfortable clothing and plan to stay near the testing site for a short time. Inform your healthcare provider about any medications or health conditions that could affect results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

IgG Level

Frequently asked questions

How Low or High IgG Levels Can Affect Health?
Low IgG levels may indicate an immune deficiency, making you more susceptible to infections. High IgG levels can sometimes signal chronic infections, autoimmune diseases, or other health issues. Your doctor will interpret results in the context of your medical history and symptoms.
What Are Typical IgG Reference Ranges?
Reference ranges vary by lab and can depend on age, sex, and health status. Your doctor will provide your specific results and compare them to your personal baseline. Normal ranges are not always absolute and may change over time.
Can IgG Levels Change with Age?
Yes, IgG levels can fluctuate with age. Infants and children may have lower IgG levels compared to adults, and levels can decline with age due to reduced immune function. Chronic illnesses or treatments (like chemotherapy) may also affect IgG concentrations.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy