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Hemoglobin A1c (HbA1c) with additional qualitative screening for hemoglobin variants (A1a, A1b, and deletion variants)

Published: August 9, 2026Updated: August 16, 2026

This test measures your long-term blood sugar levels and checks for specific types of hemoglobin variants that may affect how your blood sugar is managed.

Quick summary

["Helps monitor diabetes and identify unusual blood protein changes that could impact health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
103844-7
Short code
HBA1 + HBA2 Del Amn/CVS
Synonyms
HBA1 + HBA2 Del Amn/CVS
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why This Test Matters for Blood Sugar Control

HbA1c reflects your average blood sugar levels over the past 2–3 months by measuring the percentage of hemoglobin that has sugar molecules attached. This test is crucial for diagnosing and managing diabetes, as it provides a more stable picture than checking blood sugar at random times. Variations in hemoglobin types (like A1a, A1b, or deletions) may indicate genetic conditions or other health factors that could influence how your body processes glucose.

How the Test Works: Analyzing Blood Components

Your blood sample is analyzed using advanced techniques to separate and identify different hemoglobin types. The primary measurement (HbA1c) is done through an immunoassay method, while additional qualitative screening detects specific hemoglobin variants. This dual approach helps ensure accurate diagnosis and tailored treatment plans.

What to Expect Before and After the Test

No special preparation is needed for this test. You’ll have a small blood draw, similar to other routine lab tests. Results are typically ready within a few days. If variants are found, your healthcare provider may recommend further testing or genetic counseling.

Common Reasons for This Test

Doctors order this test to monitor diabetes, check for hereditary blood disorders, or evaluate unexplained symptoms like fatigue or anemia. It’s also used in newborn screening for conditions like sickle cell disease or thalassemia.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HbA1c Variant Screening

Frequently asked questions

What does an abnormal HbA1c or variant result mean?
An elevated HbA1c suggests poor blood sugar control, often requiring lifestyle changes or medication. Detecting hemoglobin variants may indicate genetic conditions that need further evaluation by a hematologist or genetic counselor.
Will I need to take any special steps if my results are abnormal?
If variants are found, your doctor may recommend additional tests or referrals to specialists. For HbA1c, they’ll likely adjust your diabetes management plan based on your specific needs.
Can I fast before this test?
No fasting is required for this test, as it measures long-term blood sugar levels rather than immediate readings.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy