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Hemoglobin Subtype Analysis (Quantitative, Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures different types of hemoglobin in your blood, which can help identify conditions affecting red blood cells or blood disorders.

Quick summary

["Understanding your hemoglobin composition may help diagnose or monitor certain blood-related health issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
55242-2
Short code
HBB c.20A>T Bld Ql
Synonyms
HBB c.20A>T Bld Ql
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to check for conditions like anemia, sickle cell disease, thalassemia, or other inherited blood disorders. It can also help evaluate blood transfusions or monitor treatment responses in patients with red blood cell disorders.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm or hand to draw a blood sample. If you’re concerned about pain or discomfort, let your healthcare provider know.

What the Results Mean

Results show the proportions of different hemoglobin types (e.g., hemoglobin A, A2, F, or variants like S or C). Abnormal levels may indicate genetic blood disorders or other conditions affecting red blood cells.

Common Conditions Linked to This Test

High or low levels of specific hemoglobin types can signal conditions such as sickle cell trait, thalassemia, or other hemoglobinopathies. Your doctor will interpret results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: This test is critical for diagnosing inherited blood disorders that affect hemoglobin structure, as it provides detailed information about red blood cell composition beyond standard hemoglobin A1c or total hemoglobin measurements.

Short name

Hemoglobin Subtype Profile

Frequently asked questions

What does a hemoglobin subtype profile measure exactly?
It measures the relative amounts of different hemoglobin molecules in your blood, including common types (like hemoglobin A, A2, or fetal hemoglobin) and potential variants (e.g., sickle hemoglobin).
How often should I get this test?
Your doctor will determine how often you need this test based on your health condition, symptoms, or treatment plan. Regular monitoring may be recommended for people with known blood disorders.
Can I eat or drink before this blood test?
You can eat and drink normally before the test, as no special diet is required. However, inform your healthcare provider if you’re on blood-thinning medications or have any concerns about fasting.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy