Skip to content

Hemoglobin Electrophoresis (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the types of hemoglobin in your blood, which can help identify conditions like sickle cell disease or other hemoglobinopathies.

Quick summary

["This test helps diagnose blood disorders by checking how different hemoglobin varieties are present in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
55245-5
Short code
HBB c.220G>A Bld Ql
Synonyms
HBB c.220G>A Bld Ql
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like fatigue, pain, or unusual blood test results that suggest a hemoglobin disorder. It’s also used in newborn screening or when screening for inherited blood conditions.

What to Expect Before the Test

You’ll typically have a simple blood draw from a vein in your arm. No special preparation is needed, but let your provider know if you’re on blood-thinning medication or have a bleeding disorder.

What the Results Mean

Normal results show a balanced mix of hemoglobin types, while abnormal patterns may indicate genetic blood disorders. Your provider will discuss findings with you based on your symptoms and medical history.

Common Conditions Linked to This Test

Abnormal hemoglobin electrophoresis can confirm diagnoses like sickle cell anemia, thalassemia, or other hemoglobin variants. It’s also used in newborn screening to catch conditions early.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Hb Electrophoresis

Frequently asked questions

What does an abnormal electrophoresis result mean?
An abnormal result may indicate a genetic blood disorder, such as sickle cell disease or thalassemia. Your provider will review your symptoms and test results to explain further.
How often should I get this test?
Your provider will determine how often you need this test based on your health needs, symptoms, or family history of blood disorders. Follow-up may be needed if you have a known condition.
Can diet affect hemoglobin electrophoresis results?
Diet generally does not directly affect this test’s results, but it can influence overall blood health. Focus on maintaining a balanced diet and staying hydrated for general well-being.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy