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Genetic Test for Hemoglobin Variant A1.8 (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of a rare genetic variation in your hemoglobin—a protein in red blood cells that carries oxygen. It helps identify if you carry the A1.8 variant, which may affect how your blood functions.

Quick summary

["This test helps diagnose or monitor conditions linked to hemoglobin variants."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
61160-8
Short code
HBV A181V Islt Ql Genotyp
Synonyms
HBV A181V Islt Ql Genotyp
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
genotyping
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like fatigue, anemia, or a family history of blood disorders. It’s also used in genetic counseling for conditions like sickle cell disease or thalassemia.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, similar to other routine blood tests. The sample is processed to analyze your genetic makeup for the A1.8 variant.

What the Results Mean

Results will indicate whether you carry the A1.8 variant. A positive result means the variant is present in your DNA. This information can guide further testing or treatment planning.

Common Conditions Linked to This Variant

While the A1.8 variant is rare, it may be associated with mild or moderate blood disorders. It’s important for genetic counseling, especially if you’re considering family planning or have a family history of hemoglobin-related conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Hemoglobin Variant A1.8 Genotype

Frequently asked questions

How is this test different from a hemoglobin A1c test?
This test checks for a specific genetic mutation in your DNA, not the average level of hemoglobin over time (like an A1c test). It’s used to identify inherited traits, while an A1c measures blood sugar control.
What does a positive result mean for my health?
A positive result means you carry the A1.8 variant, but it doesn’t always cause symptoms. It may require further testing or genetic counseling to understand your risk and next steps, especially if you have a family history of blood disorders.
Can this test be done on urine or saliva instead of blood?
No, this test requires a blood sample to analyze genetic material. Other genetic tests may use saliva, but this specific test needs blood for accurate detection of hemoglobin variants.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy