Hepatitis B Core Antibody, Qualitative (Serum/Plasma)
This test detects antibodies to the hepatitis B core antigen, which your immune system produces in response to infection with the hepatitis B virus. It helps determine if you’ve been exposed to the virus or if your body is mounting an immune response.
["This test helps assess past or current hepatitis B infection status."]
Key facts at a glance
- LOINC
- 110300-1
- Short code
- HBV core Ab Msmt Ser Donr
- Synonyms
- HBV core Ab Msmt Ser Donr
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test looks for specific antibodies (IgM and IgG) against the hepatitis B core antigen. IgM antibodies typically appear early in infection and can indicate an acute (recent) infection. IgG antibodies may persist longer and suggest recovery or chronic infection. This test alone does not measure the virus itself but indicates your immune system’s reaction.
Why It Matters for Your Health
Detecting hepatitis B core antibodies is important because it can help identify past exposure to the virus, even if you no longer have active symptoms. Chronic hepatitis B can lead to serious liver damage over time, so early detection is key for monitoring and managing your health.
When You Might Need This Test
Your healthcare provider may recommend this test if you have risk factors for hepatitis B, such as travel to regions with high infection rates, exposure to infected blood, or a history of unprotected sex. It may also be ordered as part of routine screening for certain groups (e.g., pregnant women, healthcare workers).
What to Expect Before the Test
No special preparation is usually needed. You’ll have a small needle inserted into a vein (typically in your arm) to draw a blood sample. This process is quick and often causes only minor discomfort.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Hep B Core Ab (Qual)
Frequently asked questions
What does a positive result mean?
Can I get vaccinated if I have a positive hepatitis B core antibody test?
How long do hepatitis B core antibodies stay in my system?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy