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Hepatitis B Core Antibody, Donor-Specific (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to the hepatitis B core antigen, which can help identify past or current hepatitis B virus (HBV) infection.

Quick summary

["Helps determine exposure to hepatitis B virus over time."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22317-2
Short code
HBV core Ab Ser Donr-aCnc
Synonyms
HBV core Ab Ser Donr-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test looks for antibodies produced by your immune system in response to the hepatitis B core antigen—a protein found in the virus. These antibodies can appear months after infection and may persist long-term, even after recovery or clearance of the virus.

Why It’s Ordered

Your healthcare provider may order this test to assess past exposure to hepatitis B, evaluate chronic infection status, or screen for HBV-related conditions like cirrhosis or liver cancer.

Sample Collection

A blood sample is drawn from a vein in your arm. The blood is processed into either serum (liquid after clotting) or plasma (liquid after centrifugation), then tested for antibodies.

What to Expect

No special preparation is needed, but fasting may not be required. You may experience mild discomfort at the injection site, and you’ll likely be asked to rest for a few minutes afterward.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results indicate prior HBV exposure, with or without current infection. Chronic infection (HBV DNA detectable) requires ongoing monitoring for liver damage. Negative results suggest no current infection, but a prior exposure cannot be ruled out without additional testing (e.g., hepatitis B surface antibody).

Short name

Hepatitis B Core Antibody (HBcAb)

Frequently asked questions

Will this test show if I have hepatitis B now?
This test alone cannot confirm active hepatitis B infection. If you suspect recent exposure, your provider may order additional tests, such as hepatitis B surface antibody or hepatitis B virus DNA testing.
Can I get hepatitis B from a blood donation if this test is positive?
Yes, if your test is positive for hepatitis B core antibodies, your blood may be screened further to prevent transmission during donation. Donors with chronic HBV infection are typically excluded from donation.
Does this test replace hepatitis B vaccination?
No. This test confirms past exposure but does not replace vaccination, which actively prevents HBV infection. Vaccination is recommended for those at risk of exposure.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy