Hemoglobin Variants by Electrophoresis (Serum)
This test measures different types of hemoglobin in your blood using electrophoresis, a method that separates hemoglobin variants based on their electrical charge. It helps identify conditions like sickle cell disease or other inherited blood disorders.
["This test helps diagnose and monitor blood disorders by identifying unusual hemoglobin forms."]
Key facts at a glance
- LOINC
- 49359-3
- Short code
- HBV DNA Mar NAA+probe-Log#
- Synonyms
- HBV DNA Mar NAA+probe-Log#
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- probe-amp-tar
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
Electrophoresis separates hemoglobin molecules based on their electrical charge when placed in an electric field. Normal hemoglobin (HbA) moves one way, while abnormal variants (e.g., HbS in sickle cell trait, HbF in fetal hemoglobin) move differently, creating distinct bands on the gel. This helps detect genetic blood disorders.
Why It’s Done
Your doctor may order this test if you have symptoms like fatigue, frequent infections, or unusual pain (e.g., joint pain), or if you have a family history of hemoglobin disorders. It’s also used to confirm or screen for conditions like sickle cell disease, thalassemia, or other inherited red blood cell disorders.
Sample Collection
A small blood sample is drawn from a vein in your arm. The blood is processed to separate serum (liquid part without clots) for testing. This is typically done in a lab setting.
Preparation
No special preparation is needed, but inform your doctor about any medications or recent illnesses that might affect results. Avoid smoking or strenuous activity 24 hours before testing if advised.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Abnormal hemoglobin patterns can indicate genetic disorders that affect red blood cell shape, function, or lifespan. For example, sickle cell trait (HbS) may cause mild symptoms, while sickle cell disease (HbSS) can lead to severe complications like anemia, pain crises, or organ damage. Early detection allows for better management and treatment planning.
Short name
Hemoglobin Electrophoresis
Frequently asked questions
What does an abnormal result mean?
How long does it take to get results?
Can I fast before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy