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Human Herpesvirus 8 (HHV-8) DNA in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of genetic material from Human Herpesvirus 8 (also called Kaposi’s sarcoma-associated herpesvirus) in your blood. It helps doctors monitor whether the virus is active in your body.

Quick summary

["This test helps track viral activity linked to certain infections or conditions, such as Kaposi sarcoma or certain lymphomas."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
45161-7
Short code
HBV DNA SerPl NAA+probe-Log#
Synonyms
HBV DNA SerPl NAA+probe-Log#
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms of an HHV-8-related illness, such as unusual skin lesions, swollen lymph nodes, or unexplained weight loss. It may also be used during treatment to check how well your body is responding to antiviral therapy.

What to Expect Before the Test

No special preparation is usually needed. You may have a small needle inserted into a vein in your arm to draw blood. This is a quick procedure, and you can usually go back to your normal activities afterward.

What the Test Results Mean

Results are typically reported as the number of viral genetic sequences detected per volume of blood. Higher levels may indicate an active infection, while lower levels suggest the virus is less active.

Common Reasons for Testing

This test is often used in people with weakened immune systems (such as those with HIV/AIDS) or those receiving certain treatments that suppress the immune system. It can also be part of monitoring for Kaposi sarcoma or other HHV-8-related diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HHV-8 Viral Load

Frequently asked questions

How does HHV-8 viral load testing differ from other viral load tests I might have heard of?
HHV-8 viral load testing specifically measures the genetic material of Human Herpesvirus 8, unlike tests for other viruses (like HIV or hepatitis) that measure viral proteins or RNA. This helps doctors focus on HHV-8-specific infections or diseases.
What are the typical reference ranges for this test?
Reference ranges can vary by lab and patient context. Your results will be compared to your own baseline or clinical needs rather than a single general range.
Can this test detect HHV-8 infection if I have no symptoms?
Yes, this test can detect HHV-8 DNA even if you don’t have symptoms. It helps identify whether the virus is present in your bloodstream, which can inform treatment decisions even if you feel well.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy