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Hepatitis B Virus Surface Antigen Genotyping (Serum/Plasma Probe)

Published: August 9, 2026Updated: August 16, 2026

This test identifies the specific genetic subtype (genotype) of the Hepatitis B virus surface antigen found in your blood. It helps determine which strain of the virus you may have, which can influence treatment decisions and infection risk.

Quick summary

["Understanding your Hepatitis B virus subtype helps guide personalized medical care."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
42322-8
Short code
HBV S+pol gene SerPl NAA+probe
Synonyms
HBV S+pol gene SerPl NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have chronic Hepatitis B infection, have been exposed to the virus, or if you’re considering treatment options. Genotyping helps ensure the most effective antiviral therapy is chosen.

What to Expect Before the Test

No special preparation is needed. A blood sample will be taken from a vein in your arm, similar to other routine blood tests. The sample is collected in a sterile tube and sent to a lab for analysis.

What the Test Results Mean

The test returns the specific genotype (e.g., A, B, C, D, E, or others) of the Hepatitis B virus surface antigen detected in your blood. This information helps doctors tailor treatment plans, monitor disease progression, and assess long-term outcomes.

Common Genotypes and Their Implications

Different genotypes of Hepatitis B can behave differently in your body. For example, some genotypes may respond better to certain medications, while others could require closer monitoring. Your provider will discuss the implications of your specific genotype with you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Hep B Surface Antigen Genotype Test

Frequently asked questions

What does my test result indicate about my health?
Your genotype result helps your healthcare team determine the best course of treatment, such as antiviral medications, and may influence how often you need follow-up tests. It also helps assess the risk of complications like cirrhosis or liver cancer.
How long will I need to wait for my results?
Results are typically available within 1 to 2 weeks, depending on lab processing times. Your provider will contact you once results are ready.
Can this test be done at home?
No, this test requires a blood sample collected by a healthcare professional in a clinical setting. It is not available for at-home testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy