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Hemoglobin Variants by Surface Antibody Binding Profile (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the types of hemoglobin in your blood, focusing on how different antibodies interact with their surfaces. Hemoglobin is the protein in red blood cells that carries oxygen. Variations in hemoglobin can sometimes be linked to conditions like sickle cell disease or other inherited blood disorders.

Quick summary

["This test helps identify unusual hemoglobin forms that may affect your health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
95205-1
Short code
HBV surface Ab Pnl SerPl
Synonyms
HBV surface Ab Pnl SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82378
SNOMED
394995008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like fatigue, pain, or unusual blood test results that suggest an inherited blood disorder. It’s also sometimes used as part of a broader evaluation for conditions affecting red blood cells or hemoglobin production.

What to Expect Before the Test

You’ll typically have a simple blood draw from a vein in your arm. No special preparation is needed, but let your provider know if you’re on blood-thinning medication or have a history of bleeding issues.

What the Test Results Mean

Results show how different antibodies bind to your hemoglobin variants. Abnormal patterns may indicate inherited conditions like thalassemia or sickle cell trait. Your provider will discuss findings in detail with you.

Common Conditions Linked to This Test

This test helps diagnose or monitor conditions like sickle cell disease, thalassemia, or other hemoglobinopathies. It can also be part of genetic screening for families with a history of these disorders.

Reference range

Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A

Specimen: serum

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Hemoglobin Variant Screening (Serum)

Frequently asked questions

What does a positive or abnormal result mean?
An abnormal result may indicate an inherited blood disorder, such as sickle cell trait or thalassemia. Your provider will explain the specific findings and next steps, such as further testing or genetic counseling.
How often should I get this test?
The frequency depends on your symptoms and medical history. If you have a known hemoglobin disorder, your provider may recommend regular monitoring. Otherwise, this test is usually ordered as needed for specific concerns.
Can I eat or drink before this test?
No special diet is required, but avoid caffeine or heavy meals before your blood draw to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy